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What is Cialis?

Cialis is the brand name for tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor. The generic version of Cialis is called, which is also sold under the name of, which is the generic name of Tadalafil. Other popular brands of Cialis include:

How does Cialis work?

The drug works by inhibiting the PDE5 enzyme in the body. This is the enzyme that breaks down the cyclic guanosine monophosphate (cGMP). This allows cGMP to stay active in the blood, causing the blood vessels to relax and allowing more blood to flow into the body. When cGMP is active, it can cause the blood vessels to dilate and relax, allowing more blood to flow in. Cialis will only help you get or maintain a strong erection once you stop taking the medication. This helps you to get or maintain a firm erection, and should you need to be sexually stimulated for Cialis to work.

How to take Cialis?

Take one tablet orally with a glass of water. It is important that you complete the full course of Cialis to be able to take it safely, and to have an erection for sexual activity. If you have trouble swallowing the tablet, it will be broken down, and if swallowed, you will take it with or without food. You can take it with or without food, but taking it with a heavy meal or fatty food is not advised.

How long does Cialis last?

The effects of Cialis last for up to 36 hours. However, some men will experience a delay of about a half-hour. You should not take Cialis more than once within a 24-hour period.

How long does Cialis work?

What are the side effects of Cialis?

Like all medications, Cialis can cause some side effects. The most common side effects include:

  • Headaches
  • Flushing
  • Stomach pain
  • Back pain
  • Dizziness
  • Dryness in the mouth
  • Muscle aches
  • Nausea
  • Indigestion

Other potential side effects include:

  • Nosebleeds
  • Diarrhea
  • Headache
  • Tinnitus
  • Stuffy nose

If you experience any side effects, it is important to speak to your doctor before using Cialis. They may recommend you take a different medication, or recommend you stop taking the medication and speak to your doctor as soon as possible. Stopping the medication too soon can cause a serious condition called priapism, which may cause the penis to become weak and painful, or even permanently damage the penis.

How do I take Cialis?

The generic name is Cialis, which is the active ingredient. You can take it with or without food. You should always take Cialis with a glass of water. Do not take Cialis more than once daily, and do not exceed the recommended dose. If you have trouble swallowing the tablet, you can take it with or without food. You can take Cialis with or without food. You can take it with or without water. Do not take Cialis with grapefruit juice. Grapefruit juice is not advised, as it may affect its effects. If you have side effects, talk to your doctor about which medication is best for you.

The side effects of Cialis can vary in severity from person to person.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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Note:

Cialis is a widely used medication with a high success rate in the U. S. A, top drug-food interaction, top drug-food interactions inducers, and others are listed in the table. Some medications have other in them, like the following:

  • Phenytoin: Cialis can enhance the blood pressure-lowering effects of this medication, leading to symptoms like dizziness or lightheadedness, increased heart rate, or fainting.
  • Lipids: While Cialis can be taken with or without food, consuming it with inducers, especially lipid- taxing medications like rilpivirine or indinavir, can delay its onset of action.
  • Other Medications: Some medications can affect how Cialis works, like antifungals, antibiotics, and certain antimalarials. They should be your doctor's choice if you are using Cialis.

Erectile Dysfunction

Erection problems (impotence) are very common, particularly in men over 40.

Most men occasionally fail to get or keep an erection. This is usually due to stress, tiredness, anxiety or drinking too much alcohol, and it’s nothing to worry about.

If it happens more often, it may be caused by physical or emotional problems.

Physical causes Possible cause Treatment Narrowing of penis blood vessels, high blood pressure, high cholesterol medicine to lower blood pressure, statins to lower cholesterol Hormone problems hormone replacement – for example, testosterone Side effects of prescribed medication change to medicine following discussion with GP You may also be asked to make lifestyle changes.

Do lose weight if you’re overweight stop smoking eat a healthy diet exercise daily try to reduce stress and anxiety

Don’t cycle for a while (if you cycle more than 3 hours a week) drink more than 14 units of alcohol a week

  • Side Effects

    Possible side effects

    Like all medicines, this medicine can cause side effects, although not everybody gets them. These effects are normally mild to moderate in nature.

    If you experience any of the following side effects stop using the medicine and seek medical help immediately:

    allergic reactions including rashes (frequency uncommon). chest pain – do not use nitrates but seek immediate medical assistance (frequency uncommon). priapism, a prolonged and possibly painful erection after taking CIALIS (frequency rare). If you have such an erection, which lasts continuously for more than 4 hours you should contact a doctor immediately. sudden loss of vision (frequency rare). Other side effects have been reported:

    Common (seen in 1 to 10 in every 100 patients)

    headache, back pain, muscle aches, pain in arms and legs, facial flushing, nasal congestion, and indigestion. Uncommon (seen in 1 to 10 in every 1,000 patients)

    dizziness, stomach ache, feeling sick, being sick (vomiting), reflux, blurred vision, eye pain, difficulty in breathing, presence of blood in urine, prolonged erection, pounding heartbeat sensation, a fast heart rate, high blood pressure, low blood pressure, nose bleeds, ringing in the ears, swelling of the hands, feet or ankles and feeling tired. Rare (seen in 1 to 10 in every 10,000 patients)

    fainting, seizures and passing memory loss, swelling of the eyelids, red eyes, sudden decrease or loss of hearing, hives (itchy red welts on the surface of the skin), penile bleeding, presence of blood in semen and increased sweating. Heart attack and stroke have also been reported rarely in men taking CIALIS. Most of these men had known heart problems before taking this medicine.

    Partial, temporary, or permanent decrease or loss of vision in one or both eyes has been rarely reported.

  • Before taking this medicine

    You shouldaky your(>

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    Lack of sexual desire and performance

    Tai hair transplant

    Chances are you’ll get these side effects, but this medicine are very rare.

    are there any interactions with other medicinesThis medication is not intended for use by women

    This medicine may have minor side effects, including less severe side effects

    This medicine may cause side effects, including some milder side effects, but they have been observed. These may include, but are not limited to:

    allergic reactions including rash, itching, hives, and spreading. You should seek medical help immediately (frequency rare). Rare loss of coordination. You should seek medical help right away (frequency only 1 in 1,000 patients). You may experience other side effects, including muscle aches, heart attack, irregular heartbeat, treatments for erectile dysfunction and pulmonary hypertension. Common side effects you may experience:

    You should seek medical help immediately (frequency uncommon). rare swelling of the eyelids, body and/or eyelids, heartburn, indigestion, hearing changes, blurred vision, and a sudden decrease or loss of hearing. Use with caution during pregnancy. There are no adequate studies in male genital itching or performance.

    You should seek medical help immediately (frequency only 1 in 1,000 patients). This is very rare. This medicine is rarely used in paediatric cases.

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